MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here we show that miR-31 is highl...

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Publicado en:Nat Commun
Autores principales: Lv, Cong, Li, Fengyin, Li, Xiang, Tian, Yuhua, Zhang, Yue, Sheng, Xiaole, Song, Yongli, Meng, Qingyong, Yuan, Shukai, Luan, Liming, Andl, Thomas, Feng, Xu, Jiao, Baowei, Xu, Mingang, Plikus, Maksim V., Dai, Xing, Lengner, Christopher, Cui, Wei, Ren, Fazheng, Shuai, Jianwei, Millar, Sarah E., Yu, Zhengquan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648844/
https://ncbi.nlm.nih.gov/pubmed/29051494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01059-5
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