CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

U1 snRNP plays a critical role in 5ʹ-splice site recognition and is a frequent target of alternative splicing factors. These factors transiently associate with human U1 snRNP and are not amenable for structural studies, while their Saccharomyces cerevisiae (yeast) homologs are stable components of U...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Xueni, Liu, Shiheng, Jiang, Jiansen, Zhang, Lingdi, Espinosa, Sara, Hill, Ryan C., Hansen, Kirk C., Zhou, Z. Hong, Zhao, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648754/
https://ncbi.nlm.nih.gov/pubmed/29051543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01241-9
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