An inducible mouse model of podocin-mutation-related nephrotic syndrome

Mutations in the NPHS2 gene, encoding podocin, cause hereditary nephrotic syndrome. The most common podocin mutation, R138Q, is associated with early disease onset and rapid progression to end-stage renal disease. Knock-in mice carrying a R140Q mutation, the mouse analogue of human R138Q, show devel...

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Udgivet i:PLoS One
Main Authors: Tabatabaeifar, Mansoureh, Wlodkowski, Tanja, Simic, Ivana, Denc, Helga, Mollet, Geraldine, Weber, Stefanie, Moyers, John Julius, Brühl, Barbara, Randles, Michael Joseph, Lennon, Rachel, Antignac, Corinne, Schaefer, Franz
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648285/
https://ncbi.nlm.nih.gov/pubmed/29049388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186574
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