Podocin Inactivation in Mature Kidneys Causes Focal Segmental Glomerulosclerosis and Nephrotic Syndrome

Podocin is a critical component of the glomerular slit diaphragm, and genetic mutations lead to both familial and sporadic forms of steroid-resistant nephrotic syndrome. In mice, constitutive absence of podocin leads to rapidly progressive renal disease characterized by mesangiolysis and/or mesangia...

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Hauptverfasser: Mollet, Géraldine, Ratelade, Julien, Boyer, Olivia, Muda, Andrea Onetti, Morisset, Ludivine, Lavin, Tiphaine Aguirre, Kitzis, David, Dallman, Margaret J., Bugeon, Laurence, Hubner, Norbert, Gubler, Marie-Claire, Antignac, Corinne, Esquivel, Ernie L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2009
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754108/
https://ncbi.nlm.nih.gov/pubmed/19713307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009040379
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