Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells

X-chromosome inactivation (XCI) in female lymphocytes is uniquely regulated, as the inactive X (Xi) chromosome lacks localized Xist RNA and heterochromatin modifications. Epigenetic profiling reveals that Xist RNA is lost from the Xi at the pro-B cell stage and that additional heterochromatic modifi...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Syrett, Camille M., Sindhava, Vishal, Hodawadekar, Suchita, Myles, Arpita, Liang, Guanxiang, Zhang, Yue, Nandi, Satabdi, Cancro, Michael, Atchison, Michael, Anguera, Montserrat C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648283/
https://ncbi.nlm.nih.gov/pubmed/28991910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007050
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