Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), the NOX inhibitor diphenyleneiodonium (DPI) and the...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Murphy-Marshman, Hannah, Quensel, Katherine, Shi-wen, Xu, Barnfield, Rebecca, Kelly, Jacalyn, Peidl, Alex, Stratton, Richard J., Leask, Andrew
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648211/
https://ncbi.nlm.nih.gov/pubmed/29049376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186740
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