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Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts

The role of the microenvironment in driving connective tissue disease is being increasingly appreciated. Matricellular proteins of the CCN family are signaling modifiers that are secreted by cells into the extracellular matrix microenvironment where they have profound, context-dependent effects on o...

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Bibliographic Details
Published in:PLoS One
Main Authors: Peidl, Alexander, Perbal, Bernard, Leask, Andrew
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553774/
https://ncbi.nlm.nih.gov/pubmed/31170244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218178
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