Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal

The CEST properties of EuDOTA-tetraamide complexes bearing pendant carboxylate and carboxyl ethyl esters were measured as a function of pH. The CEST signal from the Eu(3+)-bound water molecule decreased in intensity between pH 8.5 and 4.5 while the proton exchange rates (k(ex)) increased over this s...

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Bibliographic Details
Published in:Philos Trans A Math Phys Eng Sci
Main Authors: Zhang, Lei, Evbuomwan, Osasere M., Tieu, Michael, Zhao, Piyu, Martins, Andre F., Sherry, A. Dean
Format: Artigo
Language:Inglês
Published: The Royal Society Publishing 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647270/
https://ncbi.nlm.nih.gov/pubmed/29038382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsta.2017.0113
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