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5‐fluorouracil causes endothelial cell senescence: potential protective role of glucagon‐like peptide 1
BACKGROUND AND PURPOSE: 5‐fluorouracil (5FU) and its prodrug, capecitabine, can damage endothelial cells, whilst endothelial integrity is preserved by glucagon‐like peptide 1 (GLP‐1). Here, we studied the effect of 5FU on endothelial senescence and whether GLP‐1 antagonizes it. EXPERIMENTAL APPROACH...
Gorde:
| Argitaratua izan da: | Br J Pharmacol |
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| Egile Nagusiak: | , , , , , , , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
John Wiley and Sons Inc.
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5647192/ https://ncbi.nlm.nih.gov/pubmed/28127745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13725 |
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