5‐fluorouracil causes endothelial cell senescence: potential protective role of glucagon‐like peptide 1

BACKGROUND AND PURPOSE: 5‐fluorouracil (5FU) and its prodrug, capecitabine, can damage endothelial cells, whilst endothelial integrity is preserved by glucagon‐like peptide 1 (GLP‐1). Here, we studied the effect of 5FU on endothelial senescence and whether GLP‐1 antagonizes it. EXPERIMENTAL APPROACH...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Altieri, Paola, Murialdo, Roberto, Barisione, Chiara, Lazzarini, Edoardo, Garibaldi, Silvano, Fabbi, Patrizia, Ruggeri, Clarissa, Borile, Silvia, Carbone, Federico, Armirotti, Andrea, Canepa, Marco, Ballestrero, Alberto, Brunelli, Claudio, Montecucco, Fabrizio, Ameri, Pietro, Spallarossa, Paolo
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Themed Section: Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647192/
https://ncbi.nlm.nih.gov/pubmed/28127745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13725
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