Chronic drug‐induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell‐derived cardiomyocytes

BACKGROUND AND PURPOSE: In the pharmaceutical industry risk assessments of chronic cardiac safety liabilities are mostly performed during late stages of preclinical drug development using in vivo animal models. Here, we explored the potential of human induced pluripotent stem cell‐derived cardiomyoc...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Kopljar, Ivan, De Bondt, An, Vinken, Petra, Teisman, Ard, Damiano, Bruce, Goeminne, Nick, Van den Wyngaert, Ilse, Gallacher, David J, Lu, Hua Rong
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Themed Section: Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647189/
https://ncbi.nlm.nih.gov/pubmed/28094846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13713
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