No Effect of Levothyroxine and Levothyroxine-Induced Subclinical Thyrotoxicosis on the Pharmacokinetics of Sorafenib in Healthy Male Subjects

Background: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyrotropin (TSH) suppression. In the Phase 3 DTC trial (DECISION),...

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Bibliografiske detaljer
Udgivet i:Thyroid
Main Authors: Huang, Funan, Ajavon, Antoinette, Huang, Erya, Lettieri, John, Liu, Rong, Peña, Carol, Berse, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2017
Fag:
Original StudiesThyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646750/
https://ncbi.nlm.nih.gov/pubmed/28741453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2017.0085
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