No Effect of Levothyroxine and Levothyroxine-Induced Subclinical Thyrotoxicosis on the Pharmacokinetics of Sorafenib in Healthy Male Subjects

Background: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyrotropin (TSH) suppression. In the Phase 3 DTC trial (DECISION),...

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Detalles Bibliográficos
Publicado en:Thyroid
Main Authors: Huang, Funan, Ajavon, Antoinette, Huang, Erya, Lettieri, John, Liu, Rong, Peña, Carol, Berse, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2017
Assuntos:
Original StudiesThyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646750/
https://ncbi.nlm.nih.gov/pubmed/28741453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2017.0085
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