Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), we identified monoclonal antibody (MAb) 2D3, which broadly n...

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Publicado en:mSphere
Main Authors: Kolawole, Abimbola O., Smith, Hong Q., Svoboda, Sophia A., Lewis, Madeline S., Sherman, Michael B., Lynch, Gillian C., Pettitt, B. Montgomery, Smith, Thomas J., Wobus, Christiane E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646240/
https://ncbi.nlm.nih.gov/pubmed/29062895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00334-17
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