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Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG adducts. Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645340/ https://ncbi.nlm.nih.gov/pubmed/29042535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01013-5 |
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