A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease

We present a new, quantification-driven proteomic approach to identifying biomarkers. In contrast to the identification-driven approach, limited in scope to peptides that are identified by database searching in the first step, all MS data are considered to select biomarker candidates. The endopeptid...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Skillbäck, Tobias, Mattsson, Niklas, Hansson, Karl, Mirgorodskaya, Ekaterina, Dahlén, Rahil, van der Flier, Wiesje, Scheltens, Philip, Duits, Floor, Hansson, Oskar, Teunissen, Charlotte, Blennow, Kaj, Zetterberg, Henrik, Gobom, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645330/
https://ncbi.nlm.nih.gov/pubmed/29042634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13831-0
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