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Allelic Mutations in Noncoding Genomic Sequences Construct Novel Transcription Factor Binding Sites that Promote Gene Overexpression
The growth and survival factor hepatocyte growth factor (HGF) is expressed at high levels in multiple myeloma (MM) cells. We report here that elevated HGF transcription in MM was traced to DNA mutations in the promoter alleles of HGF. Sequence analysis revealed a previously undiscovered single-nucle...
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| Publicado no: | Genes Chromosomes Cancer |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644988/ https://ncbi.nlm.nih.gov/pubmed/26220195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22280 |
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