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Allelic Mutations in Noncoding Genomic Sequences Construct Novel Transcription Factor Binding Sites that Promote Gene Overexpression
The growth and survival factor hepatocyte growth factor (HGF) is expressed at high levels in multiple myeloma (MM) cells. We report here that elevated HGF transcription in MM was traced to DNA mutations in the promoter alleles of HGF. Sequence analysis revealed a previously undiscovered single-nucle...
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| 出版年: | Genes Chromosomes Cancer |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644988/ https://ncbi.nlm.nih.gov/pubmed/26220195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22280 |
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