De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks

pyrE (STM3733) encodes orotate phosphoribosyltransferase (OPRTase; EC 2.4.2.10), the fifth enzyme of the de novo pyrimidine biosynthetic pathway. We identified a ΔpyrE mutant as under selection in screening of a Salmonella mutant library in 4-day old chicks. Here, we confirm that a ΔpyrE mutant colo...

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Vydáno v:PLoS One
Hlavní autoři: Yang, Hee-Jeong, Bogomolnaya, Lydia, McClelland, Michael, Andrews-Polymenis, Helene
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644981/
https://ncbi.nlm.nih.gov/pubmed/29040285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183751
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