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De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks
pyrE (STM3733) encodes orotate phosphoribosyltransferase (OPRTase; EC 2.4.2.10), the fifth enzyme of the de novo pyrimidine biosynthetic pathway. We identified a ΔpyrE mutant as under selection in screening of a Salmonella mutant library in 4-day old chicks. Here, we confirm that a ΔpyrE mutant colo...
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| Udgivet i: | PLoS One |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644981/ https://ncbi.nlm.nih.gov/pubmed/29040285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183751 |
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