YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer

BACKGROUND: Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations identifying new modulators of COX-2 pathway and searching for new chemicals ta...

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書目詳細資料
發表在:J Exp Clin Cancer Res
Main Authors: Li, Wei, Cao, Yuanyuan, Xu, Jinling, Wang, Ying, Li, Weijie, Wang, Qian, Hu, Ziwei, Hao, Yaping, Hu, Li, Sun, Yawen, Xu, Guanglin, Ao, Guizhen
格式: Artigo
語言:Inglês
出版: BioMed Central 2017
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644195/
https://ncbi.nlm.nih.gov/pubmed/29037225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0612-3
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