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A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies

α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of kno...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Luthra, Tania, Agarwal, Rahul, Estari, Mamidala, Adepally, Uma, Sen, Subhabrata
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643545/
https://ncbi.nlm.nih.gov/pubmed/29038580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13798-y
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