Replication fork reversal triggers fork degradation in BRCA2-defective cells

Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled replication forks from nucleolytic degradation. Defective fork stability contributes to chemotherapeutic sensitivity of BRCA2-defective tumors by yet-elusive mechanisms. Using DNA fiber spreading and direct vis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Mijic, Sofija, Zellweger, Ralph, Chappidi, Nagaraja, Berti, Matteo, Jacobs, Kurt, Mutreja, Karun, Ursich, Sebastian, Ray Chaudhuri, Arnab, Nussenzweig, Andre, Janscak, Pavel, Lopes, Massimo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643541/
https://ncbi.nlm.nih.gov/pubmed/29038466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01164-5
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