A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine

Our method describes the quantification in mouse urine of trimethylamine (TMA), trimethylamine N-oxide (TMAO) and creatinine. The method combines derivatization of TMA, with ethyl bromoacetate, and LC chromatographic separation on an ACE C(18) column. The effluent was continuously electrosprayed int...

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Detalhes bibliográficos
Publicado no:MethodsX
Main Authors: Veeravalli, Sunil, Karu, Kersti, Phillips, Ian R., Shephard, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Biochemistry, Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643081/
https://ncbi.nlm.nih.gov/pubmed/29062719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mex.2017.09.004
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