Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...

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Published in:Science
Main Authors: Mok, Sachel, Ashley, Elizabeth A., Ferreira, Pedro E., Zhu, Lei, Lin, Zhaoting, Yeo, Tomas, Chotivanich, Kesinee, Imwong, Mallika, Pukrittayakamee, Sasithon, Dhorda, Mehul, Nguon, Chea, Lim, Pharath, Amaratunga, Chanaki, Suon, Seila, Hien, Tran Tinh, Htut, Ye, Faiz, M. Abul, Onyamboko, Marie A., Mayxay, Mayfong, Newton, Paul N., Tripura, Rupam, Woodrow, Charles J., Miotto, Olivo, Kwiatkowski, Dominic P., Nosten, François, Day, Nicholas P. J., Preiser, Peter R., White, Nicholas J., Dondorp, Arjen M., Fairhurst, Rick M., Bozdech, Zbynek
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642863/
https://ncbi.nlm.nih.gov/pubmed/25502316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260403
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