Characterization of a novel androgen receptor (AR) coregulator RIPK1 and related chemicals that suppress AR-mediated prostate cancer growth via peptide and chemical screening

Using bicalutamide-androgen receptor (AR) DNA binding domain-ligand binding domain as bait, we observed enrichment of FxxFY motif-containing peptides. Protein database searches revealed the presence of receptor-interacting protein kinase 1 (RIPK1) harboring one FxxFY motif. RIPK1 interacted directly...

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Vydáno v:Oncotarget
Hlavní autoři: Hsu, Cheng-Lung, Liu, Jai-Shin, Lin, Ting-Wei, Chang, Ying-Hsu, Kuo, Yung-Chia, Lin, An-Chi, Ting, Huei-Ju, Pang, See-Tong, Lee, Li-Yu, Ma, Wen-Lung, Lin, Chun-Cheng, Wu, Wen-Guey
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642495/
https://ncbi.nlm.nih.gov/pubmed/29050220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17843
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