Identification of a new androgen receptor (AR) co‐regulator BUD31 and related peptides to suppress wild‐type and mutated AR‐mediated prostate cancer growth via peptide screening and X‐ray structure analysis

Treatment with individual anti‐androgens is associated with the development of hot‐spot mutations in the androgen receptor (AR). Here, we found that anti‐androgens‐mt‐ARs have similar binary structure to the 5α‐dihydrotestosterone‐wt‐AR. Phage display revealed that these ARs bound to similar peptide...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Hsu, Cheng-Lung, Liu, Jai-Shin, Wu, Po-Long, Guan, Hong-Hsiang, Chen, Yuh-Ling, Lin, An-Chi, Ting, Huei-Ju, Pang, See-Tong, Yeh, Shauh-Der, Ma, Wen-Lung, Chen, Chung-Jung, Wu, Wen-Guey, Chang, Chawnshang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253602/
https://ncbi.nlm.nih.gov/pubmed/25091737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.009
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