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Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Amyloid β (Aβ) deposition in the brain is an early and invariable feature of Alzheimer’s disease (AD). The Aβ peptides are composed of about 40 amino acids and are generated from amyloid precursor proteins (APP), by β- and γ-secretases. The distribution of individual Aβ peptides in the brains of age...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Kakuda, Nobuto, Miyasaka, Tomohiro, Iwasaki, Noriyuki, Nirasawa, Takashi, Wada-Kakuda, Satoko, Takahashi-Fujigasaki, Junko, Murayama, Shigeo, Ihara, Yasuo, Ikegawa, Masaya
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641992/
https://ncbi.nlm.nih.gov/pubmed/29037261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0477-x
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