Targeting Wall Teichoic Acid in Situ with Branched Polyethylenimine Potentiates β-Lactam Efficacy against MRSA

[Image: see text] Methicillin-resistant Staphylococcus aureus (MRSA) is a medical concern. Here, we show that branched polyethylenimine (BPEI), a nontoxic, cationic polymer, restores MRSA’s susceptibility to β-lactam antibiotics. Checkerboard assays with MRSA demonstrated synergy between BPEI and β-...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Foxley, Melissa A., Wright, Summer N., Lam, Anh K., Friedline, Anthony W., Strange, Stoffel J., Xiao, Min T., Moen, Erika L., Rice, Charles V.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641947/
https://ncbi.nlm.nih.gov/pubmed/29057055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00285
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