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Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions
Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity are known to leak electrons to oxygen to produce O(2)(˙̄) and/or H(2)O(2). We discuss their contributions to O(2)(...
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Publicado no: | J Biol Chem |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5641882/ https://ncbi.nlm.nih.gov/pubmed/28842493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R117.789271 |
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