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Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity are known to leak electrons to oxygen to produce O(2)(˙̄) and/or H(2)O(2). We discuss their contributions to O(2)(...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wong, Hoi-Shan, Dighe, Pratiksha A., Mezera, Vojtech, Monternier, Pierre-Axel, Brand, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641882/
https://ncbi.nlm.nih.gov/pubmed/28842493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R117.789271
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