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Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity are known to leak electrons to oxygen to produce O(2)(˙̄) and/or H(2)O(2). We discuss their contributions to O(2)(...

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Foilsithe in:J Biol Chem
Main Authors: Wong, Hoi-Shan, Dighe, Pratiksha A., Mezera, Vojtech, Monternier, Pierre-Axel, Brand, Martin D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641882/
https://ncbi.nlm.nih.gov/pubmed/28842493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R117.789271
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