Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessed ex Vivo under Conditions Mimicking Rest and Exercise

The sites and rates of mitochondrial production of superoxide and H(2)O(2) in vivo are not yet defined. At least 10 different mitochondrial sites can generate these species. Each site has a different maximum capacity (e.g. the outer quinol site in complex III (site III(Qo)) has a very high capacity...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Goncalves, Renata L. S., Quinlan, Casey L., Perevoshchikova, Irina V., Hey-Mogensen, Martin, Brand, Martin D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281723/
https://ncbi.nlm.nih.gov/pubmed/25389297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619072
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