Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase

Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function mutant mice and analyzed their metabolic phenotype. Nisch-mutant embryos e...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dong, Shengli, Baranwal, Somesh, Garcia, Anapatricia, Serrano-Gomez, Silvia J., Eastlack, Steven, Iwakuma, Tomoo, Mercante, Donald, Mauvais-Jarvis, Franck, Alahari, Suresh K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641867/
https://ncbi.nlm.nih.gov/pubmed/28842496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784256
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