Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

Adoptive cell therapy (ACT) of autologous tumor infiltrating lymphocytes (TIL) is an effective immunotherapy for patients with solid tumors, yielding objective response rates of around 40% in refractory patients with metastatic melanoma. Most clinical centers utilize bulk, randomly isolated TIL from...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Seliktar-Ofir, Sivan, Merhavi-Shoham, Efrat, Itzhaki, Orit, Yunger, Sharon, Markel, Gal, Schachter, Jacob, Besser, Michal J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641376/
https://ncbi.nlm.nih.gov/pubmed/29067023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01211
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