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Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis
AIMS: Activation of the NAD(+) dependent protein deacetylase SIRT1 has been proposed as a therapeutic strategy to treat mitochondrial dysfunction and insulin resistance in skeletal muscle. However, life-long overexpression of SIRT1 in skeletal muscle does not improve parameters of mitochondrial func...
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| Publicado no: | Acta Physiol (Oxf) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5641221/ https://ncbi.nlm.nih.gov/pubmed/28544355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.12897 |
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