Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin

High-risk human papillomaviruses (HPV) cause cancer at multiple distinct anatomical locations. Regardless of the tissue of origin, most HPV positive (HPV+) cancers show highly upregulated expression of the p16 product of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene. Paradoxically, HPV+ tum...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gameiro, Steven F., Kolendowski, Bart, Zhang, Ali, Barrett, John W., Nichols, Anthony C., Torchia, Joe, Mymryk, Joe S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641152/
https://ncbi.nlm.nih.gov/pubmed/29069809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19885
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