Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation...

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Detalhes bibliográficos
Publicado no:Synth Syst Biotechnol
Main Authors: He, Wenni, Liu, Miaomiao, Huang, Pei, Abdel-Mageed, Wael M., Han, Jianying, Watrous, Jeramie D., Nguyen, Don D., Wang, Wenzhao, Song, Fuhang, Dai, Huanqin, Zhang, Jingyu, Quinn, Ronald J., Grkovi, Tanja, Luo, Houwei, Zhang, Lixin, Liu, Xueting
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Publishing 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640788/
https://ncbi.nlm.nih.gov/pubmed/29062942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2016.05.002
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