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Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation...

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Detaylı Bibliyografya
Yayımlandı:Synth Syst Biotechnol
Asıl Yazarlar: He, Wenni, Liu, Miaomiao, Huang, Pei, Abdel-Mageed, Wael M., Han, Jianying, Watrous, Jeramie D., Nguyen, Don D., Wang, Wenzhao, Song, Fuhang, Dai, Huanqin, Zhang, Jingyu, Quinn, Ronald J., Grkovi, Tanja, Luo, Houwei, Zhang, Lixin, Liu, Xueting
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: KeAi Publishing 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640788/
https://ncbi.nlm.nih.gov/pubmed/29062942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2016.05.002
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