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Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes
Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate cancer cell fraction, population recurrence, and functional impact of somatic mutations as s...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5640613/ https://ncbi.nlm.nih.gov/pubmed/29030609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12888-1 |
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