Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

KCC2 is a neuron-specific K(+)-Cl(–) cotransporter essential for establishing the Cl(-) gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement. Aberrant...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Mahadevan, Vivek, Khademullah, C Sahara, Dargaei, Zahra, Chevrier, Jonah, Uvarov, Pavel, Kwan, Julian, Bagshaw, Richard D, Pawson, Tony, Emili, Andrew, De Koninck, Yves, Anggono, Victor, Airaksinen, Matti, Woodin, Melanie A
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640428/
https://ncbi.nlm.nih.gov/pubmed/29028184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28270
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