A kainate receptor subunit promotes the recycling of the neuron-specific K(+)-Cl(−) co-transporter KCC2 in hippocampal neurons

Synaptic inhibition depends on a transmembrane gradient of chloride, which is set by the neuron-specific K(+)-Cl(−) co-transporter KCC2. Reduced KCC2 levels in the neuronal membrane contribute to the generation of epilepsy, neuropathic pain, and autism spectrum disorders; thus, it is important to ch...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pressey, Jessica C., Mahadevan, Vivek, Khademullah, C. Sahara, Dargaei, Zahra, Chevrier, Jonah, Ye, Wenqing, Huang, Michelle, Chauhan, Alamjeet K., Meas, Steven J., Uvarov, Pavel, Airaksinen, Matti S., Woodin, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391750/
https://ncbi.nlm.nih.gov/pubmed/28235805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.767236
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