Systematic integration of biomedical knowledge prioritizes drugs for repurposing

The ability to computationally predict whether a compound treats a disease would improve the economy and success rate of drug approval. This study describes Project Rephetio to systematically model drug efficacy based on 755 existing treatments. First, we constructed Hetionet (neo4j.het.io), an inte...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Himmelstein, Daniel Scott, Lizee, Antoine, Hessler, Christine, Brueggeman, Leo, Chen, Sabrina L, Hadley, Dexter, Green, Ari, Khankhanian, Pouya, Baranzini, Sergio E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640425/
https://ncbi.nlm.nih.gov/pubmed/28936969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26726
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