Systematic integration of biomedical knowledge prioritizes drugs for repurposing

The ability to computationally predict whether a compound treats a disease would improve the economy and success rate of drug approval. This study describes Project Rephetio to systematically model drug efficacy based on 755 existing treatments. First, we constructed Hetionet (neo4j.het.io), an inte...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Himmelstein, Daniel Scott, Lizee, Antoine, Hessler, Christine, Brueggeman, Leo, Chen, Sabrina L, Hadley, Dexter, Green, Ari, Khankhanian, Pouya, Baranzini, Sergio E
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Computational and Systems Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640425/
https://ncbi.nlm.nih.gov/pubmed/28936969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26726
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