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Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study

BACKGROUND: Treatment response to systemic corticosteroid in asthmatic children is heterogeneous and may be mediated by epigenetic mechanism(s). We aim to identify DNA methylation (DNAm) changes responsive to steroid, and DNAm biomarkers that distinguish treatment response. MATERIALS AND METHODS: We...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Xue, Biagini Myers, Jocelyn M., Yadagiri, Veda K., Ulm, Ashley, Chen, Xiaoting, Weirauch, Matthew T., Khurana Hershey, Gurjit K., Ji, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640236/
https://ncbi.nlm.nih.gov/pubmed/29028809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186150
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