Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the haematopoietic stem cells

Recent studies demonstrated that prolonged exposure of haematopoietic stem cells (HSCs) to type I interferons (IFN) stimulates HSCs entrance into cell cycle, continuous proliferation and eventual exhaustion, which could be prevented by ablation of the Ifnar1 chain of IFN receptor. Given that levels...

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Veröffentlicht in:Cancer Biol Ther
Hauptverfasser: Gui, Jun, Zhao, Bin, Lyu, Kaosheng, Tong, Wei, Fuchs, Serge Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639844/
https://ncbi.nlm.nih.gov/pubmed/28678581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1345395
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