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Prion-like Domains Program Ewing’s Sarcoma
Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the a...
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| Veröffentlicht in: | Cell |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5639709/ https://ncbi.nlm.nih.gov/pubmed/28938120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.010 |
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