Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice

The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unstable karyotypes and germline transmission is unreli...

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Udgivet i:Stem Cell Reports
Main Authors: Shinohara, Takashi, Kazuki, Kanako, Ogonuki, Narumi, Morimoto, Hiroko, Matoba, Shogo, Hiramatsu, Kei, Honma, Kazuhisa, Suzuki, Teruhiko, Hara, Takahiko, Ogura, Atsuo, Oshimura, Mitsuo, Kanatsu-Shinohara, Mito, Kazuki, Yasuhiro
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639258/
https://ncbi.nlm.nih.gov/pubmed/28943251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.08.012
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