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MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis

MCPH1 gene, mutated in primary microcephaly, regulates cell progression into mitosis. While this role has been extensively investigated in the context of DNA damage, its function during unperturbed cell cycles has been given less attention. Here we have analyzed the dynamics of chromosome condensati...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Arroyo, M., Kuriyama, R., Trimborn, M., Keifenheim, D., Cañuelo, A., Sánchez, A., Clarke, D. J., Marchal, J. A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638862/
https://ncbi.nlm.nih.gov/pubmed/29026105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12793-7
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