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MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis

MCPH1 gene, mutated in primary microcephaly, regulates cell progression into mitosis. While this role has been extensively investigated in the context of DNA damage, its function during unperturbed cell cycles has been given less attention. Here we have analyzed the dynamics of chromosome condensati...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Arroyo, M., Kuriyama, R., Trimborn, M., Keifenheim, D., Cañuelo, A., Sánchez, A., Clarke, D. J., Marchal, J. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638862/
https://ncbi.nlm.nih.gov/pubmed/29026105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12793-7
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