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Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1

TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries. Here we demonstrate that TorsinA assembles into homotypic oligomers in t...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Chase, Anna R., Laudermilch, Ethan, Wang, Jimin, Shigematsu, Hideki, Yokoyama, Takeshi, Schlieker, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638581/
https://ncbi.nlm.nih.gov/pubmed/28814508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-05-0281
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