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Role of the N-terminus for the stability of an amyloid-β fibril with three-fold symmetry

A key player in Alzheimer’s disease is the peptide amyloid-beta (Aβ), whose aggregation into small soluble oligomers, protofilaments, and fibrils finally leads to plaque deposits in human brains. The aggregation behavior of Aβ is strongly modulated by the nature and composition of the peptide’s envi...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Söldner, Christian A., Sticht, Heinrich, Horn, Anselm H. C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638522/
https://ncbi.nlm.nih.gov/pubmed/29023579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186347
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