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The Conformational Stability of Nonfibrillar Amyloid-β Peptide Oligomers Critically Depends on the C-Terminal Peptide Length

[Image: see text] The amyloid-β (Aβ) peptide is one key molecule in the pathogenesis of Alzheimer’s disease. We investigated the conformational stability of a nonfibrillar tetrameric Aβ structure by molecular dynamics (MD) simulations revealing that the stability of the Aβ tetramer depends criticall...

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Bibliographic Details
Main Authors: Socher, Eileen, Sticht, Heinrich, Horn, Anselm H. C.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963130/
https://ncbi.nlm.nih.gov/pubmed/24494584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400208r
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