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A platform for high-throughput screening of DNA-encoded catalyst libraries in organic solvents

We have developed a novel high-throughput screening platform for the discovery of small-molecules catalysts for bond-forming reactions. The method employs an in vitro selection for bond-formation using amphiphilic DNA-encoded small molecules charged with reaction substrate, which enables selections...

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Publicado en:Chem Sci
Autores principales: Hook, K. Delaney, Chambers, John T., Hili, Ryan
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637469/
https://ncbi.nlm.nih.gov/pubmed/29147535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02779f
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